Журнал «Microbiology Independent Research Journal (MIR journal)»

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Influenza vaccines manufacturing in continuous cell lines: problems and solutions

Опубликована: 2017-03-30

Julia Romanova

In order to decrease the morbidity and mortality caused by seasonal influenza outbreaks, several hundred million vaccine doses are produced worldwide each year. The predominant substrate for the production of …

Changes in the antigenic and genetic structure of influenza viruses: analysis of surveillance data of influenza A and B in Russia in 2006-2013

Опубликована: 2015-10-13

Mikhail P. Grudinin, Maria M. Pisareva, Andrey B. Komissarov, Anna A. Kosheleva, Zhanna V. Buzitskaya, Marina A. Stukova, Alexandra V. Prokopetz, Daria M. Danilenko, Nadezhda I. Konovalova, Tamara G. Lobova, Anna A. Sominina, Oleg I. Kiselev

The goal of this research project was to study the natural variability of human influenza A and B viruses based on the analysis of the population structure of influenza viruses, …

Fighting bacterial resistance: approaches, challenges, and opportunities in the search for new antibiotics. Part 1. Antibiotics used in clinical practice: mechanisms of action and the development of bacterial resistance

Опубликована: 2017-12-24

Alexander Zhivich

Hundreds of thousands of people are dying every year in the world from infections caused by drug resistant bacteria. Antibiotic resistance is a rapidly increasing problem mostly as a result …

Two years of experience in hospital surveillance for the severe influenza like illnesses in St. Petersburg: etiology, clinical characterization of diseases, antigenic and genetic properties of isolated influenza viruses

Опубликована: 2015-11-17

Anna A. Sominina, Maria M. Pisareva, Mikhail P. Grudinin, Mikhail Yu. Eropkin, Nadezhda I. Konovalova, Vera F. Sukhovetskaya, Olga I. Afanasieva, Lubov V. Voloshuk, Andrey B. Komissarov, Zhanna V. Buzitskaya, Artem V. Fadeev, Kirill A. Stolyarov, Elizaveta A. Smorodintseva, Veronika S. Afanasieva, Marina A. Yanina, Vitalii V. Gonchar, Ludmila V. Osidak, Alexey A. Go

In this paper, we analyze the etiology of the diseases occurring during two consecutive influenza epidemic seasons in St. Petersburg, Russian Federation. The analysis is based on the results of …

Factors affecting the immunogenicity of the live attenuated influenza vaccine produced in continuous cell line

Опубликована: 2016-05-08

Andrea Wolkerstorfer, Dietmar Katinger, Julia Romanova

The biological basis for the restricted immunogenicity of some live attenuated influenza vaccine strains generated on the backbone of the cold adapted (ca) A/Singapore/1/1957/ca (H2N2) influenza A virus master strain …

The challenges of creating a universal influenza vaccine

Опубликована: 2016-07-10

Andrej Y. Egorov

The lack of population immunity to the periodically emerging pandemic influenza strains makes influenza infection especially dangerous. The fragmented nature of the influenza virus genome contributes to the formation of …

Effect of triazavirine on the outcome of a lethal influenza infection and secondary bacterial pneumonia following inﬂuenza in mice

Опубликована: 2018-02-22

Irina A. Leneva, Irina N. Falynskova, Nailya R. Makhmudova, Ekaterina A. Glubokova, Nadezhda P. Kartashova, Eugenia I. Leonova, Natalya A. Mikhailova, Irina V. Shestakova

Pneumonia often occurs as secondary infection post influenza disease and accounts for a large proportion of the morbidity and mortality associated with seasonal and pandemic influenza outbreaks. The antiviral drug …

H5N1 influenza vaccine quality is affected by hemagglutinin conformational stability

Mariia Sergeeva, Artem Krokhin, Mikhail Matrosovich, Tatyana Matrosovich, Markus Wolschek, Oleg Kiselev, Julia Romanova

Since 1997, highly pathogenic H5N1 avian influenza viruses have circulated in wild and domestic birds and sporadically have infected humans. Conventional inactivated vaccines made from these viruses were shown to …

A new safe and effective cold-adapted modified live equine influenza virus vaccine that enables the differentiation of infected from vaccinated animals

Опубликована: 2016-10-09

Kaissar Tabynov

An analysis of the main advantages and shortcomings of the existing inactivated and live vaccines against the equine influenza viruses (EIVs) is given in this paper. For the first time, …

The influenza epidemic in Russia in 2014–2015 season

Опубликована: 2016-04-17

Ludmila S. Karpova, Nina M. Popovtseva, Tatyana P. Stolyarova, Nadezhda I. Konovalova, Mikhail Y. Eropkin, Elena I. Burtzeva, Elena L. Feodoritova, Anna A. Sominina

The goal of this study was to compare the data on the intensity of the influenza A(H3N2) and B epidemic (especially the death toll) in the 2014–2015 season with the …

Development of the A/H6N1 influenza vaccine candidate based on A/Leningrad/134/17/57 (H2N2) master donor virus and the genome composition analysis using high resolution melting (HRM)

Опубликована: 2016-09-15

Yulia A. Desheva, Tatiana A. Smolonogina, Galina O. Landgraf, Larisa G. Rudenko

The avian influenza viruses of H6N1subtype present a potential danger for humans. The cold-adapted (ca) reassortant influenza virus А/17/herring gull/Sarma/2006/887 (H6N1) was obtained in chicken embryos by the genetic reassortment …

Mutations in human genes that increase the risk for severe influenza infection

Опубликована: 2015-09-09

O. I. Kiselev, A. B. Komissarov, O.S.Konshina, M.N.Dmitrieva, E.G.Deyeva, T.V.Sologub, V.I.Pokrovskiy

The system of genetic control of innate immune responses to influenza infection and gene function allows for the development of systemic treatment of influenza with a focus on the phenotype …

Development of the cell-ELISA test for the subtype identification of circulating influenza A(H1) and A(H3) viruses

Опубликована: 2016-06-02

Vera Krivitskaya, Evgeniy Sorokin, Tatyana Tsareva, Ekaterina Petrova, Nadezhda Konovalova, Maria Pisareva, Zhanna Buzitskaya, Tatyana Smirnova, Anna Sominina

The sensitive version of cell-ELISA was developed for the subtype-specific differentiation of current influenza A(H1N1)pdm09 and A(H3N2) viruses that are circulating in the human population. This method is based on …

Influence of single amino acid substitutions in the hemagglutinin on antigenic and receptor-binding properties of influenza virus B/Florida/04/2006 of Yamagata-like evolutionary lineage

Опубликована: 2016-09-08

Evgeniy V. Sorokin, Tatyana R. Tsareva, Anna A. Sominina, Maria M. Pisareva, Andrey B. Komissarov, Аnna А. Kosheleva

Influenza A and B viruses use sialylated oligosaccharide chains expressed on the surface of a host cell as the cell entry receptors. The type of the bond between sialic acid …

Live poultry vaccines against highly pathogenic avian influenza viruses

Опубликована: 2018-08-13

Elizaveta Boravleva, Alexandra Gambaryan

The widespread circulation of highly pathogenic avian influenza viruses (HPAIVs) and their occasional transmission to humans creates a constant pandemic threat and leads to significant economic losses in the poultry …

The use of microarrays for the identification of the origin of genes of avian influenza viruses in wild birds

Опубликована: 2017-12-16

Rustam N. Heydarov, Natalia F. Lomakina, Elizaveta Yu. Boravleva, Ivan S. Kholodilov, Alexandra S. Gambaryan, Vladimir M. Mikhailovich, Eugene E. Fesenko

Forty-two strains of avian influenza viruses were isolated from the wild waterfowls’ feces in the city of Moscow. These viruses, as well as reference strains and some experimental reassortants, were analyzed …

Discovering science: what opportunities does Open Access give?

Maria Debabova

The concept of Open Access first appeared in the media 16 years ago. The main source of this concept was formulated within the framework of the Budapest Initiative [1] that became …

The problem of bacterial complications post respiratory viral infections

Опубликована: 2018-07-05

Andrej Egorov

Every person over the course of their lifetime is repeatedly infected by a variety of respiratory viruses that represent risk factors for the development of bacterial complications. The most dangerous …

Drug development and open access: approaches and perspectives

Опубликована: 2018-08-15

Dmitri V. Debabov, Maria D. Debabova

The development of a new medicine is a process that requires enormous time and tremendous financing. It takes 10-15 years from the discovery of an active compound to the launch …

Enhancement of the immunogenicity of influenza A virus by the inhibition of immunosuppressive function of NS1 protein

Опубликована: 2018-11-22

Kirill A. Vasilyev, Maria A. Yukhneva, Anna-Polina S. Shurygina, Marina A. Stukova, Andrej Y. Egorov

The truncation of the nonstructural NS1 protein is a novel approach for the generation of immunogenic attenuated influenza viruses. However, the innate immune mechanisms that cause the increased immunogenicity of …

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15.01.2019

Редакционная коллегия журнала MIR Journal объявляет конкурс на лучшую статью по микробиологии 2019 года

В связи с успешным проведением конкурса среди научных работников, аспирантов и студентов на лучшую научную публикацию 2018г. редакционная коллегия MIR Journal приняла решение повторить конкурс на лучшую статью по микробиологии (бактериологии, вирусологии, микологии) в 2019г.

01.01.2019

Итоги конкурса научного журнала MIR Journal среди научных работников, аспирантов и студентов на лучшую научную публикацию 2018 года по микробиологии

26.04.2018

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За второе место (два приза) – 20000 руб.
За третье место (три приза) – 12000 руб.

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