The Microbiology Independent Research (MIR) journal

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Adaptation of the quantitative PCR method for the detection of the main representatives of cereal grain mycobiota

published: 2018-12-31

Aleksandra S. Orina, Olga P. Gavrilova, Tatiana Yu. Gagkaeva

The content of fungal DNA and mycotoxins in cereal crops (31 varieties of wheat, oats, and barley) was quantitatively determined and used for the comparative characterization of grains. The quantitative …

First report of the fungus Diaporthe phaseolorum on sunflower in Russia

published: 2018-12-22

Maria M. Gomzhina, Philipp B. Gannibal

Fungi of the ascomycete genus Diaporthe have been identified worldwide. Typically, Diaporthe species are saprobes, endophytes, or plant pathogens. The distinction between the species of this genus has historically been …

Enhancement of the immunogenicity of influenza A virus by the inhibition of immunosuppressive function of NS1 protein

published: 2018-11-22

Kirill A. Vasilyev, Maria A. Yukhneva, Anna-Polina S. Shurygina, Marina A. Stukova, Andrej Y. Egorov

The truncation of the nonstructural NS1 protein is a novel approach for the generation of immunogenic attenuated influenza viruses. However, the innate immune mechanisms that cause the increased immunogenicity of …

Drug development and open access: approaches and perspectives

published: 2018-08-15

Dmitri V. Debabov, Maria D. Debabova

The development of a new medicine is a process that requires enormous time and tremendous financing. It takes 10-15 years from the discovery of an active compound to the launch …

Live poultry vaccines against highly pathogenic avian influenza viruses

published: 2018-08-13

Elizaveta Boravleva, Alexandra Gambaryan

The widespread circulation of highly pathogenic avian influenza viruses (HPAIVs) and their occasional transmission to humans creates a constant pandemic threat and leads to significant economic losses in the poultry …

The problem of bacterial complications post respiratory viral infections

published: 2018-07-05

Andrej Egorov

Every person over the course of their lifetime is repeatedly infected by a variety of respiratory viruses that represent risk factors for the development of bacterial complications. The most dangerous …

Effect of triazavirine on the outcome of a lethal influenza infection and secondary bacterial pneumonia following inﬂuenza in mice

published: 2018-02-22

Irina A. Leneva, Irina N. Falynskova, Nailya R. Makhmudova, Ekaterina A. Glubokova, Nadezhda P. Kartashova, Eugenia I. Leonova, Natalya A. Mikhailova, Irina V. Shestakova

Pneumonia often occurs as secondary infection post influenza disease and accounts for a large proportion of the morbidity and mortality associated with seasonal and pandemic influenza outbreaks. The antiviral drug …

Discovering science: what opportunities does Open Access give?

Maria Debabova

The concept of Open Access first appeared in the media 16 years ago. The main source of this concept was formulated within the framework of the Budapest Initiative [1] that became …

Fighting bacterial resistance: approaches, challenges, and opportunities in the search for new antibiotics. Part 1. Antibiotics used in clinical practice: mechanisms of action and the development of bacterial resistance

published: 2017-12-24

Alexander Zhivich

Hundreds of thousands of people are dying every year in the world from infections caused by drug resistant bacteria. Antibiotic resistance is a rapidly increasing problem mostly as a result …

The use of microarrays for the identification of the origin of genes of avian influenza viruses in wild birds

published: 2017-12-16

Rustam N. Heydarov, Natalia F. Lomakina, Elizaveta Yu. Boravleva, Ivan S. Kholodilov, Alexandra S. Gambaryan, Vladimir M. Mikhailovich, Eugene E. Fesenko

Forty-two strains of avian influenza viruses were isolated from the wild waterfowls’ feces in the city of Moscow. These viruses, as well as reference strains and some experimental reassortants, were analyzed …

Influenza vaccines manufacturing in continuous cell lines: problems and solutions

published: 2017-03-30

Julia Romanova

In order to decrease the morbidity and mortality caused by seasonal influenza outbreaks, several hundred million vaccine doses are produced worldwide each year. The predominant substrate for the production of …

Development of the A/H6N1 influenza vaccine candidate based on A/Leningrad/134/17/57 (H2N2) master donor virus and the genome composition analysis using high resolution melting (HRM)

published: 2016-09-15

Yulia A. Desheva, Tatiana A. Smolonogina, Galina O. Landgraf, Larisa G. Rudenko

The avian influenza viruses of H6N1subtype present a potential danger for humans. The cold-adapted (ca) reassortant influenza virus А/17/herring gull/Sarma/2006/887 (H6N1) was obtained in chicken embryos by the genetic reassortment …

A new safe and effective cold-adapted modified live equine influenza virus vaccine that enables the differentiation of infected from vaccinated animals

published: 2016-10-09

Kaissar Tabynov

An analysis of the main advantages and shortcomings of the existing inactivated and live vaccines against the equine influenza viruses (EIVs) is given in this paper. For the first time, …

Influence of single amino acid substitutions in the hemagglutinin on antigenic and receptor-binding properties of influenza virus B/Florida/04/2006 of Yamagata-like evolutionary lineage

published: 2016-09-08

Evgeniy V. Sorokin, Tatyana R. Tsareva, Anna A. Sominina, Maria M. Pisareva, Andrey B. Komissarov, Аnna А. Kosheleva

Influenza A and B viruses use sialylated oligosaccharide chains expressed on the surface of a host cell as the cell entry receptors. The type of the bond between sialic acid …

Factors affecting the immunogenicity of the live attenuated influenza vaccine produced in continuous cell line

published: 2016-05-08

Andrea Wolkerstorfer, Dietmar Katinger, Julia Romanova

The biological basis for the restricted immunogenicity of some live attenuated influenza vaccine strains generated on the backbone of the cold adapted (ca) A/Singapore/1/1957/ca (H2N2) influenza A virus master strain …

The challenges of creating a universal influenza vaccine

published: 2016-07-10

Andrej Y. Egorov

The lack of population immunity to the periodically emerging pandemic influenza strains makes influenza infection especially dangerous. The fragmented nature of the influenza virus genome contributes to the formation of …

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15.01.2019

Competition for the best publication in 2019 (6 cash prizes for winners)

Editorial board of MIR Journal announces a competition for the best scientific publication on Microbiology (Virology, Bacteriology, Mycology) in 2019

03.01.2019

Competition results amongst all researchers, graduate students and students for the best 2018 scientific publication in MIR Journal

After reviewing the articles submitted for the competition, the following authors are pronounced winners

03.09.2018

Competition for the best publication (6 cash prizes for winners)

After the successful review process (2 positive reviews from 3 reviewers), all the manuscripts will be published in the MIR journal. The authors of the best 6 papers will be awarded

02.05.2018

How to make artificially created organisms safe?

11.03.2018

A new system for the search for antimicrobial peptides

21.05.2017

New antibiotics to fight Gram-negative bacteria

In the recent paper, "Predictive compound accumulation rules yield a broad-spectrum antibiotic", published in Nature by Michelle F. Richter et al. (Nature, London, UK, 2017, doi: 10.1038/nature22308) the group of chemists from the University of Illinois (USA) reported results of their study on accumulation of more than 150 diverse chemical compounds in E. coli