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Influenza vaccines manufacturing in continuous cell lines: problems and solutions

published: 2017-03-30

Julia Romanova

In order to decrease the morbidity and mortality caused by seasonal influenza outbreaks, several hundred million vaccine doses are produced worldwide each year. The predominant substrate for the production of …

Changes in the antigenic and genetic structure of influenza viruses: analysis of surveillance data of influenza A and B in Russia in 2006-2013

published: 2015-10-13

Mikhail P. Grudinin, Maria M. Pisareva, Andrey B. Komissarov, Anna A. Kosheleva, Zhanna V. Buzitskaya, Marina A. Stukova, Alexandra V. Prokopetz, Daria M. Danilenko, Nadezhda I. Konovalova, Tamara G. Lobova, Anna A. Sominina, Oleg I. Kiselev

The goal of this research project was to study the natural variability of human influenza A and B viruses based on the analysis of the population structure of influenza viruses, …

Two years of experience in hospital surveillance for the severe influenza like illnesses in St. Petersburg: etiology, clinical characterization of diseases, antigenic and genetic properties of isolated influenza viruses

published: 2015-11-17

Anna A. Sominina, Maria M. Pisareva, Mikhail P. Grudinin, Mikhail Yu. Eropkin, Nadezhda I. Konovalova, Vera F. Sukhovetskaya, Olga I. Afanasieva, Lubov V. Voloshuk, Andrey B. Komissarov, Zhanna V. Buzitskaya, Artem V. Fadeev, Kirill A. Stolyarov, Elizaveta A. Smorodintseva, Veronika S. Afanasieva, Marina A. Yanina, Vitalii V. Gonchar, Ludmila V. Osidak, Alexey A. Go

In this paper, we analyze the etiology of the diseases occurring during two consecutive influenza epidemic seasons in St. Petersburg, Russian Federation. The analysis is based on the results of …

Fighting bacterial resistance: approaches, challenges, and opportunities in the search for new antibiotics. Part 1. Antibiotics used in clinical practice: mechanisms of action and the development of bacterial resistance

published: 2017-12-24

Alexander Zhivich

Hundreds of thousands of people are dying every year in the world from infections caused by drug resistant bacteria. Antibiotic resistance is a rapidly increasing problem mostly as a result …

Factors affecting the immunogenicity of the live attenuated influenza vaccine produced in continuous cell line

published: 2016-05-08

Andrea Wolkerstorfer, Dietmar Katinger, Julia Romanova

The biological basis for the restricted immunogenicity of some live attenuated influenza vaccine strains generated on the backbone of the cold adapted (ca) A/Singapore/1/1957/ca (H2N2) influenza A virus master strain …

H5N1 influenza vaccine quality is affected by hemagglutinin conformational stability

Mariia Sergeeva, Artem Krokhin, Mikhail Matrosovich, Tatyana Matrosovich, Markus Wolschek, Oleg Kiselev, Julia Romanova

Since 1997, highly pathogenic H5N1 avian influenza viruses have circulated in wild and domestic birds and sporadically have infected humans. Conventional inactivated vaccines made from these viruses were shown to …

The challenges of creating a universal influenza vaccine

published: 2016-07-10

Andrej Y. Egorov

The lack of population immunity to the periodically emerging pandemic influenza strains makes influenza infection especially dangerous. The fragmented nature of the influenza virus genome contributes to the formation of …

Effect of triazavirine on the outcome of a lethal influenza infection and secondary bacterial pneumonia following inﬂuenza in mice

published: 2018-02-22

Irina A. Leneva, Irina N. Falynskova, Nailya R. Makhmudova, Ekaterina A. Glubokova, Nadezhda P. Kartashova, Eugenia I. Leonova, Natalya A. Mikhailova, Irina V. Shestakova

Pneumonia often occurs as secondary infection post influenza disease and accounts for a large proportion of the morbidity and mortality associated with seasonal and pandemic influenza outbreaks. The antiviral drug …

A new safe and effective cold-adapted modified live equine influenza virus vaccine that enables the differentiation of infected from vaccinated animals

published: 2016-10-09

Kaissar Tabynov

An analysis of the main advantages and shortcomings of the existing inactivated and live vaccines against the equine influenza viruses (EIVs) is given in this paper. For the first time, …

Live poultry vaccines against highly pathogenic avian influenza viruses

published: 2018-08-13

Elizaveta Boravleva, Alexandra Gambaryan

The widespread circulation of highly pathogenic avian influenza viruses (HPAIVs) and their occasional transmission to humans creates a constant pandemic threat and leads to significant economic losses in the poultry …

The influenza epidemic in Russia in 2014–2015 season

published: 2016-04-17

Ludmila S. Karpova, Nina M. Popovtseva, Tatyana P. Stolyarova, Nadezhda I. Konovalova, Mikhail Y. Eropkin, Elena I. Burtzeva, Elena L. Feodoritova, Anna A. Sominina

The goal of this study was to compare the data on the intensity of the influenza A(H3N2) and B epidemic (especially the death toll) in the 2014–2015 season with the …

Mutations in human genes that increase the risk for severe influenza infection

published: 2015-09-09

O. I. Kiselev, A. B. Komissarov, O.S.Konshina, M.N.Dmitrieva, E.G.Deyeva, T.V.Sologub, V.I.Pokrovskiy

The system of genetic control of innate immune responses to influenza infection and gene function allows for the development of systemic treatment of influenza with a focus on the phenotype …

Development of the A/H6N1 influenza vaccine candidate based on A/Leningrad/134/17/57 (H2N2) master donor virus and the genome composition analysis using high resolution melting (HRM)

published: 2016-09-15

Yulia A. Desheva, Tatiana A. Smolonogina, Galina O. Landgraf, Larisa G. Rudenko

The avian influenza viruses of H6N1subtype present a potential danger for humans. The cold-adapted (ca) reassortant influenza virus А/17/herring gull/Sarma/2006/887 (H6N1) was obtained in chicken embryos by the genetic reassortment …

Influence of single amino acid substitutions in the hemagglutinin on antigenic and receptor-binding properties of influenza virus B/Florida/04/2006 of Yamagata-like evolutionary lineage

published: 2016-09-08

Evgeniy V. Sorokin, Tatyana R. Tsareva, Anna A. Sominina, Maria M. Pisareva, Andrey B. Komissarov, Аnna А. Kosheleva

Influenza A and B viruses use sialylated oligosaccharide chains expressed on the surface of a host cell as the cell entry receptors. The type of the bond between sialic acid …

Development of the cell-ELISA test for the subtype identification of circulating influenza A(H1) and A(H3) viruses

published: 2016-06-02

Vera Krivitskaya, Evgeniy Sorokin, Tatyana Tsareva, Ekaterina Petrova, Nadezhda Konovalova, Maria Pisareva, Zhanna Buzitskaya, Tatyana Smirnova, Anna Sominina

The sensitive version of cell-ELISA was developed for the subtype-specific differentiation of current influenza A(H1N1)pdm09 and A(H3N2) viruses that are circulating in the human population. This method is based on …

The problem of bacterial complications post respiratory viral infections

published: 2018-07-05

Andrej Egorov

Every person over the course of their lifetime is repeatedly infected by a variety of respiratory viruses that represent risk factors for the development of bacterial complications. The most dangerous …

The use of microarrays for the identification of the origin of genes of avian influenza viruses in wild birds

published: 2017-12-16

Rustam N. Heydarov, Natalia F. Lomakina, Elizaveta Yu. Boravleva, Ivan S. Kholodilov, Alexandra S. Gambaryan, Vladimir M. Mikhailovich, Eugene E. Fesenko

Forty-two strains of avian influenza viruses were isolated from the wild waterfowls’ feces in the city of Moscow. These viruses, as well as reference strains and some experimental reassortants, were analyzed …

Discovering science: what opportunities does Open Access give?

Maria Debabova

The concept of Open Access first appeared in the media 16 years ago. The main source of this concept was formulated within the framework of the Budapest Initiative [1] that became …

Drug development and open access: approaches and perspectives

published: 2018-08-15

Dmitri V. Debabov, Maria D. Debabova

The development of a new medicine is a process that requires enormous time and tremendous financing. It takes 10-15 years from the discovery of an active compound to the launch …

Enhancement of the immunogenicity of influenza A virus by the inhibition of immunosuppressive function of NS1 protein

published: 2018-11-22

Kirill A. Vasilyev, Maria A. Yukhneva, Anna-Polina S. Shurygina, Marina A. Stukova, Andrej Y. Egorov

The truncation of the nonstructural NS1 protein is a novel approach for the generation of immunogenic attenuated influenza viruses. However, the innate immune mechanisms that cause the increased immunogenicity of …

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15.01.2019

Competition for the best publication in 2019 (6 cash prizes for winners)

Editorial board of MIR Journal announces a competition for the best scientific publication on Microbiology (Virology, Bacteriology, Mycology) in 2019

03.01.2019

Competition results amongst all researchers, graduate students and students for the best 2018 scientific publication in MIR Journal

After reviewing the articles submitted for the competition, the following authors are pronounced winners

03.09.2018

Competition for the best publication (6 cash prizes for winners)

After the successful review process (2 positive reviews from 3 reviewers), all the manuscripts will be published in the MIR journal. The authors of the best 6 papers will be awarded

02.05.2018

How to make artificially created organisms safe?

11.03.2018

A new system for the search for antimicrobial peptides

21.05.2017

New antibiotics to fight Gram-negative bacteria

In the recent paper, "Predictive compound accumulation rules yield a broad-spectrum antibiotic", published in Nature by Michelle F. Richter et al. (Nature, London, UK, 2017, doi: 10.1038/nature22308) the group of chemists from the University of Illinois (USA) reported results of their study on accumulation of more than 150 diverse chemical compounds in E. coli