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The problem of bacterial complications post respiratory viral infections


Every person in the course of lifetime is repeatedly infected by a variety of respiratory viruses that represent the risk factors for the development of bacterial complications. The most dangerous among the etiological factors of acute respiratory viral diseases is the influenza A virus. This virus is capable to cause catastrophic pandemics with high mortality mainly due to the secondary bacterial pneumonia. As it has been shown in numerous recent studies, the main mechanism of provoking bacterial infections irrespective of the type of respiratory virus is the unbalanced response of the antiviral innate immunity - excessive interferon response and uncontrolled inflammation. The probability of severe bacterial complications in the course of acute respiratory viral infections is determined by both the virulence of the virus itself and by the composition of the respiratory microbiota at the time of the viral infection, as well as by the genetic characteristics of the organism. Occurrence of severe bacterial complications is also affected by the chronic diseases that have an impact on the regulation of the innate immune response. This review summarizes the current conception of the mechanisms of development of the post viral bacterial complications as well as the possibilities of prevention of these complications.

About the Author

A. Egorov
University of Natural Resources and Life Sciences; Mechnikov Research Institute for Vaccines and Sera

Andrej Egorov





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Egorov A. The problem of bacterial complications post respiratory viral infections. Microbiology Independent Research Journal (MIR Journal). 2018;5(1):1-11. (In Russ.)

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