ISSN 2500-2236
DOI-prefix: 10.18527/2500-2236

The risk of developing Clostridium difficile infection associated with various groups of antibiotics and their combinations in treatment of children at pediatric oncological hospital

Abstract


Patients at the children’s pediatric oncological hospital are at risk of developing Clostridium difficile infection. The purpose of this study was to determine the degree of risk of developing Clostridium difficile infection in patients of the pediatric oncological hospital using various groups of antibiotics and their combinations. Analysis of experimental data showed that the use of antibacterial drugs belonging to the groups of nitrofurans (enterofuryl), sulfonamides (biseptol), cephalosporins and macrolides / azalides, led to statistically significant increase of the risk of Clostridium difficile infection in hospitalized children. The use of antibiotics such as linezolid, colistin and metronidazole led to statistically significant decrease of the risk of developing Clostridium difficile infection. The use of penicillins, aminoglycosides, fluoroquinolones, glycopeptides, carbapenems was not associated with the risk of Clostridium difficile infection in children undergoing treatment in an oncological hospital. The use of one or the combination of two antibacterial drugs from different groups increased the risk of developing Clostridium difficile infection when compared with the combination of drugs from three different groups. 

 

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