ISSN 2500-2236
DOI-prefix: 10.18527/2500-2236

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Volume 4, Number 1, 2017
... both of these cell lines is higher than the pH essential for triggering a conformational change of the hemagglutinin (HA) of human influenza viruses, which enables the viral-cellular membrane fusion ...
Authors: Julia Romanova
Том 1, номер 1, 2014
... change (pH of fusion or activation) of avian highly pathogenic influenza viruses resulted in the low stability of native HA conformation and affected the vaccine quality. The 58Lys→Ile mutation ...
Authors: М.В. Сергеева, А. Крохин, М. Матросович, Т. Матросович, М. Волшек, О.И. Киселев, Ю.Р. Романова
Volume 3, Number 1, 2016
... proximity to the viral membrane is highly conservative and characterized by low immunogenicity [11]. The main function of the HA2 subunit is to ensure the fusion of the ...
Authors: Andrej Y. Egorov
Volume 1, number 1, 2014
... plates and the amount of hemoglobin released by virus-cell fusion induced hemolysis was determined by measuring the optical density (OD) at 415 nm. The presented results are the mean values of three ...
Authors: Mariia Sergeeva, Artem Krokhin, Mikhail Matrosovich, Tatyana Matrosovich, Markus Wolschek, Oleg Kiselev, Julia Romanova
Том 4, номер 1, 2017
... both of these cell lines is higher than the pH essential for triggering a conformational change of the hemagglutinin (HA) of human influenza viruses, which enables the viral-cellular membrane fusion ...
Authors: Ю.Р. Романова
Volume 3, Number 1, 2016
... , pH 9.5) with nitro blue tetrazolium and 5-bromo-4-chloro-3-indolyl phosphate. Determination of fusion pH by hemolysis Sucrose purified viruses in PBS, adjusted to an ...
Authors: Andrea Wolkerstorfer, Dietmar Katinger, Julia Romanova
Volume 5, Number 1, 2018
... necessary for the fusion of virus and cellular membranes in order to deliver the virus genome to the cytoplasm. This pH is known as the pH of fusion or pH of activation. Virus dk/4182 as a typical ...
Authors: Elizaveta Boravleva, Alexandra Gambaryan
Volume 4, Number 1, 2017
... -adapted A/CA/04/09 virus. Two antiviral drugs with a different mechanism of action – neuraminidase inhibitor oseltamivir and fusion inhibitor umifenovir – were used as the controls. A high ...
Authors: Irina A. Leneva, Irina N. Falynskova, Nailya R. Makhmudova, Ekaterina A. Glubokova, Nadezhda P. Kartashova, Eugenia I. Leonova, Natalya A. Mikhailova, Irina V. Shestakova
Volume 2, Number 1, 2015
... recognized by the CR6261 antibody. The neutralizing effect of this antibody is associated with HA fusion [16]. According to the molecular modeling data, the ...
Authors: Mikhail P. Grudinin, Maria M. Pisareva, Andrey B. Komissarov, Anna A. Kosheleva, Zhanna V. Buzitskaya, Marina A. Stukova, Alexandra V. Prokopetz, Daria M. Danilenko, Nadezhda I. Konovalova, Tamara G. Lobova, Anna A. Sominina, Oleg I. Kiselev